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Of 877 samples tested, 127 neutralized with at least one of the four flaviviruses (14.5, 95% CI 12.3–17.0%), with a higher proportion in Turkana (21.1%, n = 87/413) than in West Pokot (8.6%, n = 40/464).

Zika virus seroprevalence was significantly higher in West Pokot (7.11%) than in Turkana County (0.24%; χYellow fever virus (YFV), Dengue virus (DENV), West Nile virus (WNV) and Zika virus (ZIKV) are important mosquito-borne Flaviviruses that have a potential to cause severe disease and mortalities in humans with economic and ecological consequence [1, 2].

However, the extent of human exposure to these viruses and associated disease burden in Kenya and Africa at large remains unknown.

We assessed the seroprevalence of Yellow fever and other Flaviviruses in human populations in West Pokot and Turkana Counties of Kenya.

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